This study describes the identification of an antibiotic class acting via LpxH, involved in lipopolysaccharide synthesis having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Further development of this class of antibiotics could make an important contribution to the ongoing struggle against antibiotic resistance.
https://www.pnas.org/doi/10.1073/pnas.2317274121 (open access)
Also, gotta keep the supply of animal products up somehow! (/s, end animal agriculture)