The uniform here is interesting, because the comic takes place after DS9, but before “Nemesis”, around 2377. Other than the crews of the Theseus, and Defiant, characters wear the “First Contact” uniforms, yet Shaw and the other Starfleets we see on this cover are wearing the early DS9/VOY uniforms.

Obviously there could be some time travel shenanigans, which would place this in 2373 at the latest. Shaw was an ensign during the Battle of Wolf 359 in 2366, and on this cover we see him rocking commander pips, so he would have progressed up the ranks in about seven years. Obviously a thing that can happen in Trek, as we’ve seen, but somewhere in the Delta Quadrant Harry Kim just punched a bulkhead and has no idea why.