Sure, you could have ran RotT in a number of sourceports, DOSBox, or even a virtual machine if you were determined, but the experience of getting it up and running on a modern system hasn’t been great.
Nightdive released Ludicrous Edition and it’s finally accessible enough to just launch and play. Includes midi and 2013 soundtracks, all the original episodes, plus one new one, and a couple of qol adjustments in the menus.
I’ve played it for about two hours, and the only hitch I’ve noticed is the midi ost can stutter. If you swap it for OPL, it’s fine, though.